Beilstein J. Org. Chem.2014,10, 1151–1158, doi:10.3762/bjoc.10.115
efficient solid-phase-supportedpeptidesynthesis (SPPS) of morpholinoglycine oligonucleotide (MorGly) mimics has been developed. The proposed strategy includes a novel specially designed labile linker group containing the oxalyl residue and the 2-aminomethylmorpholino nucleoside analogues as first subunits
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Keywords: labile linker; morpholino oligomers; oligonucleotide mimics; solid-phase-supportedpeptidesynthesis (SPPS); Introduction
The phosphorodiamidate morpholino oligomers (PMO) and peptide conjugated PMO (PPMO) are currently promising candidates for antisense therapy of a number of infectious and
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Graphical Abstract
Figure 1:
Morpholinoglycine oligomers (A) and protected monomers 1a–e (B) for their synthesis.